cystathionine βsynthase（CBS）

Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4.2.1.22) that in humans is encoded by the CBS gene. It catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine：

L-serine + L-homocysteine L-cystathionine + H₂O

CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds.

CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria.

 

Recombinant Protein （EC 4.2.1.22 ）

Cat#：Abt-P-1006

Stock buffer ：PBS，pH7.4

  Isoelectric point： 6.49

pH Stability：7.4-8.5

MW： 56 KD

Purity ：≥90%（by SDS-PAGE）

Storage/Stability：

The lyophilized powder should be stored at -20 where it is stable for up to several years . The solution could be stored at 4 where it is stable for up to 1 year. Repeated freezing and thawing cycles of the reconstituted solution is not recommended .

Application：This protein can be used for producing Hcy  in vitro diagnosis  Kit .

Application Disclaimer ：Not for Therapeutic Use .